Costanzo Antegnati (9 December 1549 - 14 November 1624) was an organist, organ builder and composer.
He was born in Brescia, to a family of prolific organ builders, a profession which also included his father Graziadio. His was musically educated by Giovanni Contino and Girolamo Cavazzoni.At age 21, he was sent by his father, who reassured the Duke Guglielmo Gonzaga of his son's abilities, to fix the organ of the basilica of Santa Barbara in Mantua. Additionally, Costanzo worked with his father in the construction of the Antegnati organ, at one time the largest and most famous in the world, which was built in 1581 for the friars of St. Joseph's Church in Brescia.

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